Nxn^tm1Hmik
Targeted Allele Detail

Summary

• Symbol: Nxn^tm1Hmik
• Name: nucleoredoxin; targeted mutation 1, Hiroaki Miki
• MGI ID: MGI:4881787
• Gene: Nxn Location: Chr11:76148052-76289967 bp, - strand Genetic Position: Chr11, 45.92 cM
• Alliance: Nxn^tm1Hmik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167570
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 3 and all of exon 4 were replaced with a lacZ and neo cassette. The absence of protein expression was confirmed by western blot analysis on osteoblast extracts. (J:167570)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nxn Mutation: 502 strains or lines available

References

• Original: J:167570 Funato Y, et al., Nucleoredoxin sustains Wnt/beta-catenin signaling by retaining a pool of inactive dishevelled protein. Curr Biol. 2010 Nov 9;20(21):1945-52
• All: 1 reference(s)