About   Help   FAQ
Nxntm1Hmik
Targeted Allele Detail
Summary
Symbol: Nxntm1Hmik
Name: nucleoredoxin; targeted mutation 1, Hiroaki Miki
MGI ID: MGI:4881787
Gene: Nxn  Location: Chr11:76148052-76289967 bp, - strand  Genetic Position: Chr11, 45.92 cM
Alliance: Nxntm1Hmik page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167570
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 3 and all of exon 4 were replaced with a lacZ and neo cassette. The absence of protein expression was confirmed by western blot analysis on osteoblast extracts. (J:167570)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nxn Mutation:  502 strains or lines available
References
Original:  J:167570 Funato Y, et al., Nucleoredoxin sustains Wnt/beta-catenin signaling by retaining a pool of inactive dishevelled protein. Curr Biol. 2010 Nov 9;20(21):1945-52
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/22/2024
MGI 6.24
The Jackson Laboratory