Arhgef15^tm1.1Meg
Targeted Allele Detail

Summary

• Symbol: Arhgef15^tm1.1Meg
• Name: Rho guanine nucleotide exchange factor 15; targeted mutation 1.1, Michael E Greenberg
• MGI ID: MGI:4882034
• Synonyms: E5^fl
• Gene: Arhgef15 Location: Chr11:68833981-68848306 bp, - strand Genetic Position: Chr11, 42.21 cM
• Alliance: Arhgef15^tm1.1Meg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167914
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4, and a floxed allele neo cassette was inserted downstream of exon 8. Cre-mediated recombination removed neo cassette. (J:167914)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef15 Mutation: 48 strains or lines available

References

• Original: J:167914 Margolis SS, et al., EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. Cell. 2010 Oct 29;143(3):442-55
• All: 1 reference(s)