Arhgef5^tm1.2Meg
Targeted Allele Detail

Summary

• Symbol: Arhgef5^tm1.2Meg
• Name: Rho guanine nucleotide exchange factor 5; targeted mutation 1.2, Michael E Greenberg
• MGI ID: MGI:4882035
• Synonyms: E5^-, Ephexin5^-
• Gene: Arhgef5 Location: Chr6:43242578-43266250 bp, + strand Genetic Position: Chr6, 21.15 cM
• Alliance: Arhgef5^tm1.2Meg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167914
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 8 along with the neo cassette were removed by cre-mediated recombination. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:167914)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef5 Mutation: 72 strains or lines available

References

• Original: J:167914 Margolis SS, et al., EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. Cell. 2010 Oct 29;143(3):442-55
• All: 5 reference(s)