Irx3^tm1Hui
Targeted Allele Detail

Summary

• Symbol: Irx3^tm1Hui
• Name: Iroquois related homeobox 3; targeted mutation 1, Chi-chung Hui
• MGI ID: MGI:4882110
• Synonyms: Irx3^LacZ, Irx3^tauLacZ
• Gene: Irx3 Location: Chr8:92525139-92528282 bp, - strand Genetic Position: Chr8, 44.55 cM
• Alliance: Irx3^tm1Hui page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168037
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding portion of exon 1 was replaced with a tauLacZ and an inverted HSV-neo cassette via homologous recombination. LacZ expression recapitulates endogenous gene expression. (J:175992)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irx3 Mutation: 25 strains or lines available

References

• Original: J:168037 Kim B, et al., Primordial germ cell proliferation is impaired in Fused Toes mutant embryos. Dev Biol. 2011 Jan 15;349(2):417-26
• All: 10 reference(s)