Gys1^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Gys1^tm1.1Arte
• Name: glycogen synthase 1, muscle; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:4882117
• Synonyms: GS^R582A
• Gene: Gys1 Location: Chr7:45084268-45106043 bp, + strand Genetic Position: Chr7, 29.31 cM
• Alliance: Gys1^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167911
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 14 was replaced with a modified exon 14 in which nucleotide substitutions result in the amino acid substitution of alanine for arginine at position 582 (R582A). An FRT-flanked neo cassette inserted downstream of the modified exon 14 was removed by flp-mediated recombination. (J:167911)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gys1 Mutation: 57 strains or lines available

References

• Original: J:167911 Bouskila M, et al., Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle. Cell Metab. 2010 Nov 3;12(5):456-66
• All: 3 reference(s)