Ucp2^tm2.1Lowl
Targeted Allele Detail

Summary

• Symbol: Ucp2^tm2.1Lowl
• Name: uncoupling protein 2 (mitochondrial, proton carrier); targeted mutation 2.1, Bradford B Lowell
• MGI ID: MGI:4887236
• Synonyms: Ucp2^lox
• Gene: Ucp2 Location: Chr7:100142565-100148832 bp, + strand Genetic Position: Chr7, 54.36 cM
• Alliance: Ucp2^tm2.1Lowl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167906
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting construct was used to introduce loxP sites into intron 2 and intron 6 of Ucp2, as well as an FRT-flanked kanamycin selection cassette. Homologous recombination in W4 ES cells was used to generate the floxed allele. Chimeras were bred to Flp recombinase expressing mice to remove the selection marker cassette. (J:167906)

Expression

In Mice Carrying this Mutation:

10 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ucp2 Mutation: 41 strains or lines available

References

• Original: J:167906 Kong D, et al., Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab. 2010 Nov 3;12(5):545-52
• All: 19 reference(s)