Cacna2d3^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Cacna2d3^tm1Pngr
• Name: calcium channel, voltage-dependent, alpha2/delta subunit 3; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:4887240
• Gene: Cacna2d3 Location: Chr14:28626900-29443821 bp, - strand Genetic Position: Chr14, 16.8 cM, cytoband B
• Alliance: Cacna2d3^tm1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167904
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector, containing a lacZ gene cassette, was inserted into exon 15 via homologous recombination. Western blot analysis confirmed the absence of protein expression in brains from homozygous mice. (J:167904)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna2d3 Mutation: 64 strains or lines available

References

• Original: J:167904 Neely GG, et al., A genome-wide Drosophila screen for heat nociception identifies alpha2delta3 as an evolutionarily conserved pain gene. Cell. 2010 Nov 12;143(4):628-38
• All: 2 reference(s)