Hormad1^tm1Rajk
Targeted Allele Detail

Summary

• Symbol: Hormad1^tm1Rajk
• Name: HORMA domain containing 1; targeted mutation 1, Aleksandar Rajkovic
• MGI ID: MGI:4887242
• Gene: Hormad1 Location: Chr3:95466988-95494982 bp, + strand Genetic Position: Chr3, 40.74 cM, cytoband F2
• Alliance: Hormad1^tm1Rajk page

Adult testes are atrophied in Hormad1^tm1Rajk/Hormad1^tm1Rajk mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167522
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 4 and 5 were replaced with a neomycin resistance gene. Small amounts of truncated RNA transcripts were detectable on RT-PCR, and Western blot analysis on testis extracts showed absence of the protein. (J:167522)

Generation of the Hormad1^tm1Rajk allele

Expression

In Mice Carrying this Mutation:	33 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hormad1 Mutation: 32 strains or lines available

References

• Original: J:167522 Shin YH, et al., Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. PLoS Genet. 2010;6(11):e1001190
• All: 7 reference(s)