Ddah1^tm1Yjch
Targeted Allele Detail

Summary

• Symbol: Ddah1^tm1Yjch
• Name: dimethylarginine dimethylaminohydrolase 1; targeted mutation 1, Yingjie Chen
• MGI ID: MGI:4887350
• Synonyms: DDAH1^flox
• Gene: Ddah1 Location: Chr3:145464447-145600032 bp, + strand Genetic Position: Chr3, 70.63 cM, cytoband H3
• Alliance: Ddah1^tm1Yjch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168130
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4 was flanked by loxP sites and an FRT flanked neomycin selection cassette was inserted immediately downstream of the loxP site in intron 4. (J:168130)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ddah1 Mutation: 18 strains or lines available

References

• Original: J:168130 Hu X, et al., Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine. Circulation. 2009 Dec 1;120(22):2222-9
• All: 6 reference(s)