Gt(ROSA)26Sor^{tm1.1(Otx2)Daac}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(Otx2)Daac}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Dario Acampora
• MGI ID: MGI:4887449
• Synonyms: R26^Otx2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(Otx2)Daac} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166896
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(Otx2)Daac} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Otx2 (MGI:97451)

• Mutation details: A vector containing a floxed neo/STOP cassette followed by the mouse cDNA and an IRES-GFP. Cre-mediated recombination removed the neo/STOP cassette. (J:166896)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:166896 Di Salvio M, et al., Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP. Nat Neurosci. 2010 Dec;13(12):1481-8
• All: 2 reference(s)