Tg(Fabp1-Nr1h3)#Wexi
Transgene Detail

Summary

• Symbol: Tg(Fabp1-Nr1h3)#Wexi
• Name: transgene insertion, Wen Xie
• MGI ID: MGI:4887983
• Synonyms: VP-LXRalpha
• Transgene: Tg(Fabp1-Nr1h3)#Wexi Location: unknown
• Alliance: Tg(Fabp1-Nr1h3)#Wexi page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fabp1-Nr1h3)#Wexi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Nr1h3 (MGI:1352462)

• Mutation details: The rat Fabp1 promoter (nucleotides -596 to +21) was used to drive expression of mouse Nr1h3 in the liver and intestine. The VP16 activation domain of the Herpes simplex virus was fused to the 5' end of the Nr1h3 cDNA. (J:136468)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:136468 Uppal H, et al., Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Hepatology. 2007 Feb;45(2):422-32
• All: 2 reference(s)