Tle5^tm1.1Mmt
Targeted Allele Detail

Summary

• Symbol: Tle5^tm1.1Mmt
• Name: TLE family member 5, transcriptional modulator; targeted mutation 1.1, Makoto M Taketo
• MGI ID: MGI:4888012
• Synonyms: Aes^f
• Gene: Tle5 Location: Chr10:81395322-81402196 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Tle5^tm1.1Mmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168065
• Parent Cell Line: D3a2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by two loxP sites, and after the first loxP site a PGK-Neo cassette flanked by FRT sequences was inserted into intron 1 immediately 5' to exon 2. The PGK-Neo selection sequence was removed by FLPe-mediated recombination. (J:168065)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tle5 Mutation: 19 strains or lines available

References

• Original: J:168065 Sonoshita M, et al., Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling. Cancer Cell. 2011 Jan 18;19(1):125-37
• All: 4 reference(s)