Dlg4^tm4.1Grnt
Targeted Allele Detail

Summary

• Symbol: Dlg4^tm4.1Grnt
• Name: discs large MAGUK scaffold protein 4; targeted mutation 4.1, Seth G N Grant
• MGI ID: MGI:4888250
• Synonyms: PSD95^SH3W470L
• Gene: Dlg4 Location: Chr11:69908029-69938107 bp, + strand Genetic Position: Chr11, 42.96 cM, cytoband B4
• Alliance: Dlg4^tm4.1Grnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168384
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the SH3 domain was exchanged for a floxed neo cassette and a modified exon in which nucleotide substitutions result in the amino acid substitution of lysine for tryptophan at position 470 (W470L). Cre-mediated recombination removed the neo cassette. (J:168384)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlg4 Mutation: 44 strains or lines available

References

• Original: J:168384 Arbuckle MI, et al., The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. EMBO Rep. 2010 Jun;11(6):473-8
• All: 1 reference(s)