Igfbp3^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Igfbp3^tm1Lex
• Name: insulin-like growth factor binding protein 3; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:4888286
• Gene: Igfbp3 Location: Chr11:7156086-7163923 bp, - strand Genetic Position: Chr11, 4.75 cM
• Alliance: Igfbp3^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168345
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a lacZ/neo cassette. The absence of circulating protein was confirmed by ELISA and immunoblotting. (J:168345)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igfbp3 Mutation: 21 strains or lines available

References

• Original: J:168345 Yamada PM, et al., Evidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation. Endocrinology. 2010 Dec;151(12):5741-50
• All: 6 reference(s)