Braf^tm1.1Eyc
Targeted Allele Detail

Summary

• Symbol: Braf^tm1.1Eyc
• Name: Braf transforming gene; targeted mutation 1.1, Alain Eychene
• MGI ID: MGI:4888303
• Synonyms: B-raf^delta8b
• Gene: Braf Location: Chr6:39580171-39702397 bp, - strand Genetic Position: Chr6, 18.43 cM
• Alliance: Braf^tm1.1Eyc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168330
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 8b, and a loxP site was inserted downstream of exon 8b. Cre mediated recombination removed the neo cassette and exon 8b. (J:168330)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Braf Mutation: 60 strains or lines available

References

• Original: J:168330 Valluet A, et al., B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse. PLoS One. 2010;5(12):e15272
• All: 1 reference(s)