Cxcl12^tm1.1Ystz
Targeted Allele Detail

Summary

• Symbol: Cxcl12^tm1.1Ystz
• Name: C-X-C motif chemokine ligand 12; targeted mutation 1.1, Yi-Shiuan Tzeng
• MGI ID: MGI:4888352
• Synonyms: CXCL12F
• Gene: Cxcl12 Location: Chr6:117145496-117158328 bp, + strand Genetic Position: Chr6, 54.81 cM, cytoband F1
• Alliance: Cxcl12^tm1.1Ystz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168434
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 2, and a loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette leaving exon 2 floxed. (J:168434)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcl12 Mutation: 25 strains or lines available

References

• Original: J:168434 Tzeng YS, et al., Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression. Blood. 2011 Jan 13;117(2):429-39
• All: 5 reference(s)