Lamtor1^tm1Moka
Targeted Allele Detail

Summary

• Symbol: Lamtor1^tm1Moka
• Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 1; targeted mutation 1, Masato Okada
• MGI ID: MGI:4888381
• Synonyms: p18-Deficient
• Gene: Lamtor1 Location: Chr7:101555044-101561110 bp, + strand Genetic Position: Chr7, 54.68 cM, cytoband F1
• Alliance: Lamtor1^tm1Moka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168293
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced by a neo cassette. The absence of protein expression was confirmed by western blot analysis of mouse embryonic fibroblasts. (J:168293)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lamtor1 Mutation: 22 strains or lines available

References

• Original: J:168293 Nada S, et al., The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. EMBO J. 2009 Mar 4;28(5):477-89
• All: 2 reference(s)