Fasl^tm1.1Cgm
Targeted Allele Detail

Summary

• Symbol: Fasl^tm1.1Cgm
• Name: Fas ligand; targeted mutation 1.1, Geert Michel
• MGI ID: MGI:4888490
• Synonyms: FasL deltaIntra
• Gene: Fasl Location: Chr1:161608260-161616064 bp, - strand Genetic Position: Chr1, 69.95 cM
• Alliance: Fasl^tm1.1Cgm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168406
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with one in which the sequence corresponding to the intracellular domain (amino acids 2 through 78) was removed. A floxed neo cassette used for selection was removed by cre-mediated recombination. (J:168406)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fasl Mutation: 37 strains or lines available

References

• Original: J:168406 Luckerath K, et al., Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain. Blood. 2011 Jan 13;117(2):519-29
• All: 1 reference(s)