Itgal^tm1.1Mshi
Targeted Allele Detail

Summary

• Symbol: Itgal^tm1.1Mshi
• Name: integrin alpha L; targeted mutation 1.1, Motomu Shimaoka
• MGI ID: MGI:4888587
• Synonyms: Itgal^I306A, Itgal^{tm1(I306A)Mshi}
• Gene: Itgal Location: Chr7:126895432-126934310 bp, + strand Genetic Position: Chr7, 69.44 cM
• Alliance: Itgal^tm1.1Mshi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168533
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting vector containing an I306A mutation in exon 9 and a self-excising loxP-flanked ACE (angiotensin-converting enzyme promoter)-cre-neomycin resistance cassette (also called ACN) in intron 9 was introduced to Bruce-4 C57BL/6-derived embryonic stem cells. Deletion of the floxed segment occurred during spermatogenesis, leaving a single loxP site. (J:168533)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itgal Mutation: 76 strains or lines available

References

• Original: J:168533 Park EJ, et al., Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes. Blood. 2010 Feb 25;115(8):1572-81
• All: 2 reference(s)