Atrx^tm1Enl
Targeted Allele Detail

Summary

• Symbol: Atrx^tm1Enl
• Name: ATRX, chromatin remodeler; targeted mutation 1, En Li
• MGI ID: MGI:4888669
• Synonyms: ATRX^deltaE2, Atrx^tm1Ikit
• Gene: Atrx Location: ChrX:104841221-104972978 bp, - strand Genetic Position: ChrX, 47.26 cM
• Alliance: Atrx^tm1Enl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168608
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a splice acceptor and IRES-beta-geo cassette. The reduction in protein expression was confirmed by western blot analysis on brain extracts. (J:168608)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atrx Mutation: 78 strains or lines available

References

• Original: J:168608 Nogami T, et al., Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice. Hippocampus. 2011 Jun;21(6):678-87
• All: 5 reference(s)