Hcn4^tm1.1Ggc
Targeted Allele Detail

Summary

• Symbol: Hcn4^tm1.1Ggc
• Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4; targeted mutation 1.1, Giacomo Consalez
• MGI ID: MGI:4888968
• Synonyms: Hcn4^lox, Hcn4^tm1.1Ddf
• Gene: Hcn4 Location: Chr9:58730695-58770458 bp, + strand Genetic Position: Chr9, 31.8 cM, cytoband C
• Alliance: Hcn4^tm1.1Ggc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168248
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neomycin selection cassette was inserted upstream of exon 2 and exon 2 was flanked with loxP sites. Mice were then crossed to transgenic mice expressing flp recombinase to excise the neomycin selection cassette. (J:168248)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcn4 Mutation: 67 strains or lines available

References

• Original: J:168248 Baruscotti M, et al., Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1705-10
• All: 1 reference(s)