Hdac3^tm1.1Laz
Targeted Allele Detail

Summary

• Symbol: Hdac3^tm1.1Laz
• Name: histone deacetylase 3; targeted mutation 1.1, Mitchell A Lazar
• MGI ID: MGI:4889069
• Synonyms: HDAC3^f, HDAC3^flox
• Gene: Hdac3 Location: Chr18:38070024-38088073 bp, - strand Genetic Position: Chr18, 19.81 cM, cytoband B3
• Alliance: Hdac3^tm1.1Laz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168224
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neo cassette and left exons 4 through 7 floxed. (J:178911)

Expression

In Mice Carrying this Mutation:	7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hdac3 Mutation: 33 strains or lines available

References

• Original: J:168224 McQuown SC, et al., HDAC3 is a critical negative regulator of long-term memory formation. J Neurosci. 2011 Jan 12;31(2):764-74
• All: 41 reference(s)