Mtor^tm1Lgm
Targeted Allele Detail

Summary

• Symbol: Mtor^tm1Lgm
• Name: mechanistic target of rapamycin kinase; targeted mutation 1, Laboratory of Genetics
• MGI ID: MGI:4889219
• Synonyms: Mtor^Delta, neo-mTOR KI
• Gene: Mtor Location: Chr4:148533068-148642140 bp, + strand Genetic Position: Chr4, 78.76 cM, cytoband E1
• Alliance: Mtor^tm1Lgm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168600
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 12 was replaced with one from BALB/c, which contains the polymorphism encoding a cysteine instead of argininge at position 628 (R628C), and an FRT- and loxP-flanked neo cassette. This is a hypomorphic allele. (J:168600)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtor Mutation: 115 strains or lines available

References

• Original: J:168600 Zhang S, et al., Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production. Blood. 2011 Jan 27;117(4):1228-38
• All: 4 reference(s)