Rheb^tm1.1Pfw
Targeted Allele Detail

Summary

• Symbol: Rheb^tm1.1Pfw
• Name: Ras homolog enriched in brain; targeted mutation 1.1 Paul Worley
• MGI ID: MGI:4939473
• Synonyms: Rheb1^-
• Gene: Rheb Location: Chr5:25007821-25047359 bp, - strand Genetic Position: Chr5, 11.93 cM
• Alliance: Rheb^tm1.1Pfw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168571
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked PGK-neo cassette and second loxP site were inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed exon 3 and the neo cassette. (J:168571)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rheb Mutation: 26 strains or lines available

References

• Original: J:168571 Zou J, et al., Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell. 2011 Jan 18;20(1):97-108
• All: 1 reference(s)