Gt(ROSA)26Sor^{tm1(CAG-Rheb*)Pfw}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Rheb*)Pfw}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Paul Worley
• MGI ID: MGI:4939476
• Synonyms: Rosa26-Rheb1k, Rosa26-Rheb(S16H)
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Rheb*)Pfw} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168571
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Rheb*)Pfw} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rheb (MGI:97912)

• Mutation details: A construct consisting of the CMV beta-actin enhancer/promoter, a floxed PGK-EM7-neo-tPA cassette, a myc tagged Rheb cDNA containing an S16H mutation, and an SV40 poly(A) signal, was inserted via homologous recombination. Expression of the Rheb cDNA is silenced prior to cre mediated recombination. (J:168571)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:168571 Zou J, et al., Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell. 2011 Jan 18;20(1):97-108
• All: 4 reference(s)