Ptpn6^m1Amgn
Chemically induced Allele Detail

Summary

• Symbol: Ptpn6^m1Amgn
• Name: protein tyrosine phosphatase, non-receptor type 6; mutation 1, Amgen
• MGI ID: MGI:4939486
• Synonyms: line 4489, Ptpn6^I482F, scabby ears
• Gene: Ptpn6 Location: Chr6:124697670-124715672 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Ptpn6^m1Amgn page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to T transversion in exon 13 that results in the amino acid substitution of phenylalanine for isoleucine at position 482 (I482F). (J:168664)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn6 Mutation: 49 strains or lines available

References

• Original: J:168664 Babij P, et al., New variants in the Enpp1 and Ptpn6 genes cause low BMD, crystal-related arthropathy, and vascular calcification. J Bone Miner Res. 2009 Sep;24(9):1552-64
• All: 1 reference(s)