Slc6a3^tm1Wzh
Targeted Allele Detail

Summary

• Symbol: Slc6a3^tm1Wzh
• Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1, Wenbo Zhou
• MGI ID: MGI:4939491
• Synonyms: DAT-GFP
• Gene: Slc6a3 Location: Chr13:73684866-73726791 bp, + strand Genetic Position: Chr13, 40.1 cM
• Alliance: Slc6a3^tm1Wzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168866
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A GFP and neo cassette were inserted upstream of the first coding exon. The absence of protein expression was confirmed by western blot analysis on striatum extract. (J:168866)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a3 Mutation: 66 strains or lines available

References

• Original: J:168866 Zhou W, et al., Embryonic stem cells with GFP knocked into the dopamine transporter yield purified dopamine neurons in vitro and from knock-in mice. Stem Cells. 2009 Dec;27(12):2952-61
• All: 1 reference(s)