Pnpla3^tm1Eek
Targeted Allele Detail

Summary

• Symbol: Pnpla3^tm1Eek
• Name: patatin-like phospholipase domain containing 3; targeted mutation 1, Erin E Kershaw
• MGI ID: MGI:4939497
• Gene: Pnpla3 Location: Chr15:84052038-84071437 bp, + strand Genetic Position: Chr15, 39.78 cM, cytoband E3
• Alliance: Pnpla3^tm1Eek page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168857
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 1 was replaced with a neo cassette. The absence of transcript expression was confirmed by RNA analysis on white adipose tissue, brown adipose tissue, adrenal, and liver extracts. (J:168857)

Generation of the Pnpla3^tm1Eek allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pnpla3 Mutation: 28 strains or lines available

References

• Original: J:168857 Basantani MK, et al., Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome. J Lipid Res. 2011 Feb;52(2):318-29
• All: 3 reference(s)