Elovl2^tm1Jaco
Targeted Allele Detail

Summary

• Symbol: Elovl2^tm1Jaco
• Name: ELOVL fatty acid elongase 2; targeted mutation 1, Anders Jacobsson
• MGI ID: MGI:4939584
• Gene: Elovl2 Location: Chr13:41335858-41373879 bp, - strand Genetic Position: Chr13, 20.38 cM
• Alliance: Elovl2^tm1Jaco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168856
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 3 was replaced with a neo cassette. The absence of transcript expression was confirmed by quantitative RT-PCR on liver and testis extract. (J:168856)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elovl2 Mutation: 13 strains or lines available

References

• Original: J:168856 Zadravec D, et al., ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice. J Lipid Res. 2011 Feb;52(2):245-55
• All: 3 reference(s)