Irf8^tm1.1Hm
Targeted Allele Detail

Summary

• Symbol: Irf8^tm1.1Hm
• Name: interferon regulatory factor 8; targeted mutation 1.1, Herbert Morse III
• MGI ID: MGI:4939593
• Synonyms: Irf8^f
• Gene: Irf8 Location: Chr8:121463097-121483433 bp, + strand Genetic Position: Chr8, 70.05 cM
• Alliance: Irf8^tm1.1Hm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168923
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was floxed. The FRT-flanked neo cassette used for selection was removed by flp-mediated recombination. (J:168923)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf8 Mutation: 35 strains or lines available

References

• Original: J:168923 Feng J, et al., IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools. J Immunol. 2011 Feb 1;186(3):1458-66
• All: 44 reference(s)