Tirap^tm1.1Pjh
Targeted Allele Detail

Summary

• Symbol: Tirap^tm1.1Pjh
• Name: toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; targeted mutation 1.1, Paul J Hertzog
• MGI ID: MGI:4939795
• Gene: Tirap Location: Chr9:35095847-35111587 bp, - strand Genetic Position: Chr9, 19.99 cM, cytoband A5.3
• Alliance: Tirap^tm1.1Pjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168781
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 2 and 3 were flanked by loxP sites. Cre-mediated recombination removed exons 2 and 3. (J:168781)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tirap Mutation: 15 strains or lines available

References

• Original: J:168781 Greenhill CJ, et al., IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3. J Immunol. 2011 Jan 15;186(2):1199-208
• All: 2 reference(s)