Ren1^tm1.1Sig
Targeted Allele Detail

Summary

• Symbol: Ren1^tm1.1Sig
• Name: renin 1 structural; targeted mutation 1.1, Curt Sigmund
• MGI ID: MGI:4939805
• Synonyms: sREN^flox
• Gene: Ren1 Location: Chr1:133278412-133288058 bp, + strand Genetic Position: Chr1, 57.91 cM
• Alliance: Ren1^tm1.1Sig page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169129
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6J-Tyr^c-2J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 1a (Ia). An additional loxP site was inserted downstream of exon 1a (Ia). Flp-mediated recombination removed the neo cassette leaving exon 1a (Ia) floxed. (J:169129)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ren1 Mutation: 35 strains or lines available

Notes

ES cell = SCR (C57BL/6J-Tyr^c-2J)

References

• Original: J:169129 Xu D, et al., Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension. 2009 Dec;54(6):1240-7
• All: 4 reference(s)