Ren1^tm1.2Sig
Targeted Allele Detail

Summary

• Symbol: Ren1^tm1.2Sig
• Name: renin 1 structural; targeted mutation 1.2, Curt Sigmund
• MGI ID: MGI:4939806
• Synonyms: sRen^-
• Gene: Ren1 Location: Chr1:133278412-133288058 bp, + strand Genetic Position: Chr1, 57.91 cM
• Alliance: Ren1^tm1.2Sig page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169129
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6J-Tyr^c-2J

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination of Ren1^tm1.1Sig removed exon 1a (Ia). The absence of the transcript encoding the secreted isoform was confirmed by RT-PCR. Expression of the transcript encoding the intracellular isoform is maintained. (J:169129)

Expression

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ren1 Mutation: 35 strains or lines available

Notes

ES cell = SCR (C57BL/6J-Tyr^c-2J)

References

• Original: J:169129 Xu D, et al., Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension. 2009 Dec;54(6):1240-7
• All: 1 reference(s)