Rims2^tm1.1Sud
Targeted Allele Detail

Summary

• Symbol: Rims2^tm1.1Sud
• Name: regulating synaptic membrane exocytosis 2; targeted mutation 1.1, Thomas C Sudhof
• MGI ID: MGI:4939895
• Synonyms: RIM2alphabetagamma^floxed
• Gene: Rims2 Location: Chr15:39061681-39547768 bp, + strand Genetic Position: Chr15, 15.45 cM, cytoband C
• Alliance: Rims2^tm1.1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168840
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 26 was replaced with an FRT-flanked neo cassette and a floxed ECFP-tetracysteine tagged exon 26. Flp-mediated recombination removed the neo cassette leaving the tagged exon 26 floxed. (J:168840)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rims2 Mutation: 250 strains or lines available

References

• Original: J:168840 Kaeser PS, et al., RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell. 2011 Jan 21;144(2):282-95
• All: 29 reference(s)