Kit^tm1Rosay
Targeted Allele Detail

Summary

• Symbol: Kit^tm1Rosay
• Name: KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1, Kenton M Sanders and Seungil Ro
• MGI ID: MGI:4939904
• Synonyms: Kit+/copGFP, Kit^copGFP, Kit^{tm1(copGFP)Rosan}
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^tm1Rosay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168676
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The P1 artificial chromosome (PAC) clone 554-D1, containing exons 1-4 and a portion of intron 4 of the Kit gene, was modified by insertion of copGFP (from the copepod Pontellina plumata), a Hprt-PGK cassette, and the SV40 polyA signal downstream of the start codon. (J:168676)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 182 strains or lines available

References

• Original: J:168676 Ro S, et al., A model to study the phenotypic changes of interstitial cells of Cajal in gastrointestinal diseases. Gastroenterology. 2010 Mar;138(3):1068-78.e1-2
• All: 17 reference(s)