Vti1a^tm1Gfvm
Targeted Allele Detail

Summary

• Symbol: Vti1a^tm1Gfvm
• Name: vesicle transport through interaction with t-SNAREs 1A; targeted mutation 1, Gabriele Fischer von Mollard
• MGI ID: MGI:4940029
• Gene: Vti1a Location: Chr19:55304727-55615741 bp, + strand Genetic Position: Chr19, 51.35 cM, cytoband D2
• Alliance: Vti1a^tm1Gfvm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169107
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into exon 6, which encodes part of the SNARE motif. The absence of protein expression was confirmed by western blot analysis on E18.5 brain extracts. (J:169107)

Expression

In Mice Carrying this Mutation:

33 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vti1a Mutation: 50 strains or lines available

References

• Original: J:169107 Kunwar AJ, et al., Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2575-80
• All: 5 reference(s)