Adgra2^tm1.1Vlcg
Targeted Allele Detail

Summary

• Symbol: Adgra2^tm1.1Vlcg
• Name: adhesion G protein-coupled receptor A2; targeted mutation 1.1, Velocigene
• MGI ID: MGI:4940060
• Synonyms: Gpr124^Laz, Gpr124^Lz
• Gene: Adgra2 Location: Chr8:27575611-27613464 bp, + strand Genetic Position: Chr8, 15.91 cM, cytoband A3
• Alliance: Adgra2^tm1.1Vlcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169064
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Using VelociGene technology, most of the coding sequence (including exons 3 through 13) was replaced with a transmembrane domain lacZ and floxed neo cassette. Cre-mediated recombination removed the neo cassette. The absence of transcript expression was confirmed by northern blot analysis on embryo extracts. (J:102090, J:169064)

Expression

In Mice Carrying this Mutation:	66 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adgra2 Mutation: 43 strains or lines available

References

• Original: J:169064 Anderson KD, et al., Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2807-12
• All: 3 reference(s)