Hand2^tm2.1Dsr
Targeted Allele Detail

Summary

• Symbol: Hand2^tm2.1Dsr
• Name: heart and neural crest derivatives expressed 2; targeted mutation 2.1, Deepak Srivastava
• MGI ID: MGI:4940061
• Synonyms: Hand2^loxp
• Gene: Hand2 Location: Chr8:57774018-57777552 bp, + strand Genetic Position: Chr8, 29.8 cM
• Alliance: Hand2^tm2.1Dsr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169213
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette. (J:169213)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hand2 Mutation: 12 strains or lines available

References

• Original: J:169213 Tsuchihashi T, et al., Hand2 function in second heart field progenitors is essential for cardiogenesis. Dev Biol. 2011 Mar 1;351(1):62-69
• All: 3 reference(s)