Foxl2^{tm1(GFP/cre/ERT2)Pzg}
Targeted Allele Detail

Summary

• Symbol: Foxl2^{tm1(GFP/cre/ERT2)Pzg}
• Name: forkhead box L2; targeted mutation 1, Pumin Zhang
• MGI ID: MGI:4940388
• Synonyms: FoxL2-GCE, Foxl2^{tm1(GFP/cre/ERT2)Zhang}
• Gene: Foxl2 Location: Chr9:98837495-98840601 bp, + strand Genetic Position: Chr9, 51.41 cM, cytoband E4
• Alliance: Foxl2^{tm1(GFP/cre/ERT2)Pzg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159099
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Foxl2^{tm1(GFP/cre/ERT2)Pzg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Foxl2 (MGI:1349428)

• Mutation details: A targeting vector containing GFP-Cre/ERT2 cassette (GCE) and FRT site flanked Kanamycin/neomycin selection cassette was used to disrupt the exon containing the ATG translation start-site. The construct was electroporated into 129P2/OlaHsd derived E14Tg2a.4 embryonic stem (ES) cells. No green fluorescence was detected by direct fluorescence microscopy; however, immunohistochemical analysis revealed GFP expression in E18.5 embryos. (J:159099)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxl2 (mouse) Summary of all recombinase alleles driven by Foxl2. Comparative matrix view of recombinase activities Alliance mouse Foxl2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxl2 Mutation: 15 strains or lines available

References

• Original: J:159099 McMahon A, et al., Summary of mouse strains characterized by GUDMAP consortium. Unpublished. 2010
• All: 5 reference(s)