Nlgn3^tm3.1Sud
Targeted Allele Detail

Summary

• Symbol: Nlgn3^tm3.1Sud
• Name: neuroligin 3; targeted mutation 3.1, Thomas C Sudhof
• MGI ID: MGI:4940407
• Synonyms: Neuroligin 3 R704C, NL3^R704C
• Gene: Nlgn3 Location: ChrX:100342785-100364956 bp, + strand Genetic Position: ChrX, 43.95 cM
• Alliance: Nlgn3^tm3.1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184114
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Arginine 704 (exon 8) was mutated to encode cysteine (R704C) and an FRT-flanked neomycin cassette (with a single, un-used loxP site) was placed in intron 7. Flp-mediated recombination removed the neo cassette. (J:184114)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nlgn3 Mutation: 36 strains or lines available

References

• Original: J:184114 Etherton MR, et al., An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus. EMBO J. 2011 Jul 20;30(14):2908-19
• All: 3 reference(s)