Erc2^tm1.2Sud
Targeted Allele Detail

Summary

• Symbol: Erc2^tm1.2Sud
• Name: ELKS/RAB6-interacting/CAST family member 2; targeted mutation 1.2, Thomas C Sudhof
• MGI ID: MGI:4940481
• Synonyms: E2F-ELKS2 floxed, ELKS2alpha^f
• Gene: Erc2 Location: Chr14:27344385-28200494 bp, + strand Genetic Position: Chr14, 16.51 cM
• Alliance: Erc2^tm1.2Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155764
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank a 5'UTR exon, the first coding exon (with inserted in-frame tetracysteine tag), and an FRT-flanked neomycin cassette with loxP sites. Flp-mediated recombination removed the neo cassette. (J:155764)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Erc2 Mutation: 112 strains or lines available

References

• Original: J:155764 Kaeser PS, et al., ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. Neuron. 2009 Oct 29;64(2):227-39
• All: 8 reference(s)