Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Rene Bernards |
MGI ID: |
MGI:4940857 |
Synonyms: |
R26-betageo-E2F1, R26E2F1 |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr page
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Germline Transmission: |
Earliest citation of germline transmission:
J:83303
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
E2F1 (1869) |
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Mutation details: A human E2F1 cDNA was cloned downstream of a murine Pim1 promoter with a duplicated Ig heavy chain enhancer sequence. This construct was inserted downstream of a floxed beta-geo cassette and upstream of an IRES-PLAP cassette. Cre-mediated recombination of the STOP cassette is required for expression of the construct.
(J:83303)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
991 strains or lines available
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Original: |
J:83303 Scheijen B, et al., Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation. Mol Cell Biol. 2003 May;23(10):3656-68 |
All: |
4 reference(s) |
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