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Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Rene Bernards
MGI ID: MGI:4940857
Synonyms: R26-betageo-E2F1, R26E2F1
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83303
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr expresses 1 gene
 
Mutation detailsA human E2F1 cDNA was cloned downstream of a murine Pim1 promoter with a duplicated Ig heavy chain enhancer sequence. This construct was inserted downstream of a floxed beta-geo cassette and upstream of an IRES-PLAP cassette. Cre-mediated recombination of the STOP cassette is required for expression of the construct. (J:83303)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  991 strains or lines available
References
Original:  J:83303 Scheijen B, et al., Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation. Mol Cell Biol. 2003 May;23(10):3656-68
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory