Nedd4l^tm1.1Hkb
Targeted Allele Detail

Summary

• Symbol: Nedd4l^tm1.1Hkb
• Name: neural precursor cell expressed, developmentally down-regulated gene 4-like; targeted mutation 1.1, Hiroshi Kawabe
• MGI ID: MGI:4940977
• Synonyms: Nedd4-2^f, Nedd4L^f, Nedd4l^tm1.1Dro
• Gene: Nedd4l Location: Chr18:65020776-65350899 bp, + strand Genetic Position: Chr18, 37.57 cM, cytoband E1
• Alliance: Nedd4l^tm1.1Hkb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169296
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 15. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 15. Flp-mediated recombination removed the neo cassette leaving exon 15 floxed. (J:169296)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nedd4l Mutation: 73 strains or lines available

References

• Original: J:169296 Kimura T, et al., Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3216-21
• All: 10 reference(s)