Tg(Col2a1*R789C)#Waho
Transgene Detail

Summary

• Symbol: Tg(Col2a1*R789C)#Waho
• Name: transgene insertion, William A Horton
• MGI ID: MGI:4941021
• Transgene: Tg(Col2a1*R789C)#Waho Location: unknown
• Alliance: Tg(Col2a1*R789C)#Waho page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Col2a1*R789C)#Waho expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Col2a1 (MGI:88452)

• Mutation details: An Arg789Cys mutation (a C-to-T transition in exon 41) was engineered in the murine type II collagen (Col2a1). A second silent mutation was introduced to create a SmaI cleavage site in exon 41 used for monitoring the presence of the transgene. Five founders were created and progeny from two of these founders were analyzed. (J:112540)

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:112540 Gaiser KG, et al., Y-position collagen II mutation disrupts cartilage formation and skeletal development in a transgenic mouse model of spondyloepiphyseal dysplasia. J Bone Miner Res. 2002 Jan;17(1):39-47
• All: 1 reference(s)