Tg(Mt1-GH1)#Jjk
Transgene Detail

Summary

• Symbol: Tg(Mt1-GH1)#Jjk
• Name: transgene insertion, John J Kopchick
• MGI ID: MGI:4941025
• Synonyms: bGH
• Transgene: Tg(Mt1-GH1)#Jjk Location: unknown
• Alliance: Tg(Mt1-GH1)#Jjk page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mt1-GH1)#Jjk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  cattle	GH1 (280804)

• Mutation details: This transgene contains a metallothionein 1 transcriptional regulatory element linked to the first exon and intron of the bovine growth hormone, followed by exons 2-5 of the bovine growth hormone cDNA. (J:132437, J:157146)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1  Disease Model	Tg(Mt1-GH1)#Jjk/0	C57BL/6J-Tg(Mt1-GH1)#Jjk

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
adipose tissue	√
decreased percent body fat/body weight	√
behavior/neurological	√
abnormal food intake	√
cardiovascular system	√
abnormal artery morphology	√
increased heart weight	√
cardiac hypertrophy	√
increased systemic arterial systolic blood pressure	√
growth/size/body	√
increased heart weight	√
cardiac hypertrophy	√
increased body weight	√
increased kidney weight	√
increased liver weight	√
homeostasis/metabolism	√
decreased circulating leptin level	√
decreased circulating adiponectin level	√
liver/biliary system	√
increased liver weight	√
nervous system	√
increased brain weight	√
renal/urinary system	√
increased kidney weight	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg1
acromegaly IDs acromegaly       DOID:2449 MESH:D000172 NCI:C84533 UMLS_CUI:C0001206 Close	√

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:132437 Berryman DE, et al., Comparing adiposity profiles in three mouse models with altered GH signaling. Growth Horm IGF Res. 2004 Aug;14(4):309-18
• All: 17 reference(s)