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Trp53tm1.1Awbr
Targeted Allele Detail
Summary
Symbol: Trp53tm1.1Awbr
Name: transformation related protein 53; targeted mutation 1.1, AW Braithwaite
MGI ID: MGI:4941040
Synonyms: p53mdetlapro, Trp53mdeltapro
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm1.1Awbr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:169434
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Hypomorph, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 3. Exon 4 was replaced with a modified exon 4 that lacked 93 bps encoding amino acids 58 through 88 of the proline rich domain (mdeltapro). An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of the modified exon 4. Flp-mediated recombination removed the neo cassette. (J:169434)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Trp53tm1.1Awbr
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  239 strains or lines available
References
Original:  J:169434 Slatter TL, et al., p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors. Cell Death Differ. 2010 Mar;17(3):540-50
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory