Trp53^tm1.1Awbr
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1.1Awbr
• Name: transformation related protein 53; targeted mutation 1.1, AW Braithwaite
• MGI ID: MGI:4941040
• Synonyms: p53^mdetlapro, Trp53mdeltapro
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1.1Awbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169434
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Hypomorph, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. Exon 4 was replaced with a modified exon 4 that lacked 93 bps encoding amino acids 58 through 88 of the proline rich domain (mdeltapro). An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of the modified exon 4. Flp-mediated recombination removed the neo cassette. (J:169434)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm1.1Awbr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:169434 Slatter TL, et al., p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors. Cell Death Differ. 2010 Mar;17(3):540-50
• All: 5 reference(s)