Trp53tm1.1Awbr
Targeted Allele Detail
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Symbol: |
Trp53tm1.1Awbr |
Name: |
transformation related protein 53; targeted mutation 1.1, AW Braithwaite |
MGI ID: |
MGI:4941040 |
Synonyms: |
p53mdetlapro, Trp53mdeltapro |
Gene: |
Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
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Alliance: |
Trp53tm1.1Awbr page
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Germline Transmission: |
Earliest citation of germline transmission:
J:169434
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Hypomorph, Inserted expressed sequence) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 3. Exon 4 was replaced with a modified exon 4 that lacked 93 bps encoding amino acids 58 through 88 of the proline rich domain (mdeltapro). An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of the modified exon 4. Flp-mediated recombination removed the neo cassette.
(J:169434)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Trp53 Mutation: |
239 strains or lines available
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Original: |
J:169434 Slatter TL, et al., p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors. Cell Death Differ. 2010 Mar;17(3):540-50 |
All: |
5 reference(s) |
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