Atp1a4^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Atp1a4^tm1Itl
• Name: ATPase, Na+/K+ transporting, alpha 4 polypeptide; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:4941050
• Synonyms: Atp1a4^tm1Igl
• Gene: Atp1a4 Location: Chr1:172051080-172085981 bp, - strand Genetic Position: Chr1, 79.54 cM
• Alliance: Atp1a4^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169420
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 5 through 8 were replaced with a neo cassette. Sperm lack sodium-potassium ATPase activity. (J:169420)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp1a4 Mutation: 48 strains or lines available

References

• Original: J:169420 Jimenez T, et al., Na,K-ATPase alpha4 isoform is essential for sperm fertility. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):644-9
• All: 2 reference(s)