Gt(ROSA)26Sor^{tm3(myc*S62A)Rcse}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(myc*S62A)Rcse}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Rosalie C Sears
• MGI ID: MGI:4941058
• Synonyms: RFS-myc^S62A
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(myc*S62A)Rcse} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169403
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm3(myc*S62A)Rcse} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myc (MGI:97250)

• Mutation details: A cassette, which contains a floxed neo/STOP cassette and an HA-tagged murine cDNA with phosphorylation mutation that results in the amino acid substitution of alanine for serine at position 62 (T62A), was inserted into the locus. (J:169403)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:169403 Wang X, et al., Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland. Cancer Res. 2011 Feb 1;71(3):925-36
• All: 2 reference(s)