Sema4b^tm1Akum
Targeted Allele Detail

Summary

• Symbol: Sema4b^tm1Akum
• Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B; targeted mutation 1, Atsushi Kumanogoh
• MGI ID: MGI:4941169
• Gene: Sema4b Location: Chr7:79836589-79876275 bp, + strand Genetic Position: Chr7, 45.51 cM, cytoband D2
• Alliance: Sema4b^tm1Akum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169386
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5 through 8 were replaced with a neo cassette. Antibody assays confirmed the absence of protein expression on splenocyte. (J:169386)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sema4b Mutation: 298 strains or lines available

References

• Original: J:169386 Nakagawa Y, et al., Identification of Semaphorin 4B as a Negative Regulator of Basophil-Mediated Immune Responses. J Immunol. 2011 Mar 1;186(5):2881-8
• All: 1 reference(s)