Akt3^Nmf350
Chemically induced Allele Detail

Summary

• Symbol: Akt3^Nmf350
• Name: thymoma viral proto-oncogene 3; neuroscience mutagenesis facility, 350
• MGI ID: MGI:4941186
• Synonyms: Nmf350
• Gene: Akt3 Location: Chr1:176847639-177085769 bp, - strand Genetic Position: Chr1, 82.66 cM, cytoband H4-H6
• Alliance: Akt3^Nmf350 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: ENU mutagenesis induced an A to T transversion in codon 219 that results in an amino acid substitution of valine for aspatic acid at position 219 (D219V). (J:169028)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Akt3 Mutation: 42 strains or lines available

References

• Original: J:169028 Tokuda S, et al., A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice. Hum Mol Genet. 2011 Mar 1;20(5):988-99
• All: 3 reference(s)